Table 1.
Evaluation of hematological parameters in repeated dose oral subacute toxicity study of AND-2-HyP-β-CYD complex.
| Groups | Parameters | Normal control | Low dose (200 mg/kg) | Moderate dose (400 mg/kg) | High dose (666 mg/kg) | Reversal control | Reversal control of high dose (666 mg/kg) |
|---|---|---|---|---|---|---|---|
| Male | WBCB (×103 cells/μL) | 2.36 ± 0.09 | 3.17 ± 0.29 | 2.40 ± 0.22 | 2.32 ± 0.26 | 1.53 ± 0.17 | 2.09 ± 0.14 |
| RBC (×106 cells/μL | 5.57 ± 0.09 | 5.43 ± 0.05 | 6.39 ± 0.31 | 7.00 ± 0.04 | 5.24 ± 0.40 | 6.93 ± 0.32 | |
| Mean HGB (g/dL) | 12.88 ± 0.49 | 12.28 ± 0.51 | 12.70 ± 0.78 | 12.48 ± 0.59 | 9.25 ± 0.47 | 12.63 ± 0.59 | |
| HCT (%) | 39.73 ± 1.7 | 39.83 ± 0.75 | 38.77 ± 1.97 | 39.93 ± 1.23 | 37.67 ± 1.41 | 39.00 ± 0.87 | |
| MCV (fL) | 51.80 ± 0.45 | 54.83 ± 0.74 | 52.32 ± 1.49 | 52.48 ± 0.61 | 57.42 ± 2.38 | 54.80 ± 1.24 | |
| MCH (pg) | 15.07 ± 0.22 | 16.13 ± 0.34 | 14.58 ± 0.44 | 14.00 ± 0.73 | 14.63 ± 0.54 | 14.47 ± 0.86 | |
| MCHC (g/dL) | 28.95 ± 0.27 | 29.83 ± 0.59 | 30.50 ± 1.26 | 31.33 ± 0.67 | 32.03 ± 1.14 | 32.33 ± 0.99 | |
| PLT (×103 cells/μL) | 928.67 ± 0.34 | ∗ 1062.33 ± 38.75 | 1042.83 ± 78.54 | 991.00 ± 54.04 | ∗ 1316.83 ± 61.02 | ∗ 1246.67 ± 42.52 | |
| NEUT (%) | 11.56 ± 1.34 | 19.62 ± 1.96 | 17.92 ± 2.59 | 12.95 ± 0.84 | 18.00 ± 2.14 | 16.50 ± 2.30 | |
| LYM (%) | 84.55 ± 1.74 | 76.72 ± 3.52 | 69.00 ± 7.06 | 81.03 ± 1.57 | 72.48 ± 3.20 | 68.92 ± 13.04 | |
| MONO (%) | 3.57 ± 0.29 | 3.08 ± 0.14 | 3.38 ± 0.33 | 3.62 ± 0.24 | 3.95 ± 0.69 | 4.20 ± 0.62 | |
| EOS (%)∗ | 0.61 ± 0.10 | 0.43 ± 0.07 | 0.50 ± 0.07 | 0.65 ± 0.08 | 0.65 ± 0.09 | 1.08 ± 0.11 | |
| BASO (%) | 0.57 ± 0.13 | 0.65 ± 0.14 | 0.38 ± 0.12 | 0.45 ± 0.10 | 0.42 ± 0.14 | 0.63 ± 0.09 | |
|
| |||||||
| Female | WBCB (×103 cells/μL) | 2.51 ± 0.25 | 3.73 ± 0.35 | 1.96 ± 0.42 | 2.18 ± 0.30 | 1.53 ± 0.17 | 1.83 ± 0.15 |
| RBC (×106 cells/μL | 5.68 ± 0.16 | 5.47 ± 0.36 | 6.53 ± 0.13 | 7.18 ± 0.31 | 5.24 ± 0.40 | 5.97 ± 0.20 | |
| Mean HGB (g/dL) | 10.35 ± 0.40 | 9.72 ± 0.32 | 9.87 ± 0.37 | 9.65 ± 0.24 | 9.25 ± 0.47 | 8.77 ± 0.27 | |
| HCT (%) | 43.33 ± 2.14 | 43.67 ± 1.80 | 39.00 ± 1.65 | 42.27 ± 1.49 | 37.67 ± 1.41 | 45.33 ± 1.71 | |
| MCV (fL) | 52.92 ± 0.67 | 54.75 ± 1.19 | 51.97 ± 0.31 | 50.72 ± 0.65 | 57.42 ± 2.38 | 56.15 ± 0.88 | |
| MCH (pg) | 15.02 ± 0.37 | 16.43 ± 1.37 | 15.65 ± 0.88 | 15.00 ± 0.52 | 14.63 ± 0.54 | 14.88 ± 0.80 | |
| MCHC (g/dL) | 28.72 ± 0.74 | 32.18 ± 2.45 | 31.67 ± 1.71 | 32.83 ± 0.65 | 32.03 ± 1.14 | 33.97 ± 1.48 | |
| ∗ PLT (×103 cells/μL) | 927.00 ± 74.40 | 1127.67 ± 70.26 | 1191.00 ± 39.98 | 1286.33 ± 77.03 | 1316.83 ± 61.02 | 1130.00 ± 53.42 | |
| NEUT (%) | 15.55 ± 1.76 | 23.80 ± 4.05 | 17.92 ± 2.36 | 15.68 ± 1.59 | 18.00 ± 2.14 | 15.00 ± 2.21 | |
| LYM (%) | 77.30 ± 2.29 | 61.28 ± 6.58 | 70.70 ± 4.08 | 76.80 ± 2.43 | 72.48 ± 3.20 | 77.22 ± 3.61 | |
| MONO (%) | 3.32 ± 0.39 | 3.33 ± 0.36 | 3.93 ± 0.32 | 4.25 ± 0.90 | 3.95 ± 0.69 | 3.45 ± 0.35 | |
| EOS (%) | 0.42 ± 0.10 | 0.53 ± 0.11 | 0.65 ± 0.06 | 0.58 ± 0.09 | ∗ 1.15 ± 0.26 | 0.70 ± 0.07 | |
| BASO (%) | 0.58 ± 0.12 | 0.55 ± 0.10 | 0.52 ± 0.08 | 0.42 ± 0.12 | 0.42 ± 0.14 | 0.60 ± 0.10 | |
Each value represents the mean ± standard deviation (n = 6). One-way ANOVA test (P > 0.05) followed by Dunnett's test. ∗(P < 0.05) significantly different.