Table 3.
Evaluation of hematological parameters in the inhalation subacute toxicity study of AND-2-HyP-β-CYD complex.
| Groups | Parameters | Normal control | Vehicle control | Low dose | Mid dose | High dose |
|---|---|---|---|---|---|---|
| Male | WBCB (×103 cells/μL) | 6.18 ± 3.03 | 7.41 ± 4.24 | 13.32 ± 2.54 | 7.44 ± 3.2 | 8.19 ± 4.47 |
| RBC (×106 cells/μL) | 5.80 ± 2.16 | 8.76 ± 1.94 | 8.24 ± 0.41 | 8.19 ± 0.63 | 8.16 ± 1.17 | |
| Mean HGB (g/dL) | 11.67 ± 3.44 | 15.67 ± 2.73 | 14.8 ± 0.85 | 15.05 ± 0.45 | 15.1 ± 1.40 | |
| HCT (%) | 47.5 ± 10.47 | 52.75 ± 10.21 | 47.6 ± 2.19 | 49.75 ± 1.7 | 48 ± 7.41 | |
| MCV (fL) | 86.0 ± 14.49 | 61.0 ± 2.44 | 57.6 ± 1.51 | 61 ± 3.16 | 59 ± 2.91 | |
| MCH (pg) | 20.0 ± 1.82 | 17.75 ± 0.95 | 17.6 ± 0.54 | 18.25 ± 0.95 | 18.2 ± 1.09 | |
| MCHC (g/dL) | 23.5 ± 2.38 | 29.25 ± 1.25 | 30.8 ± 0.83 | 30 ± 0.00 | 31 ± 2.91 | |
| PLT (×103 cells/μL) | 637.75 ± 84.26 | 440.5 ± 122.56 | 568.2 ± 18.72 | 444.5 ± 109.36 | 466.6 ± 208.42 | |
| NEUT (%) | 16.75 ± 4.78 | 15.5 ± 8.06 | 15 ± 3.67 | 16.25 ± 4.5 | 15.2 ± 2.58 | |
| LYM (%) | 61 ± 10.78 | 69.5 ± 7.89 | 69.6 ± 9.28 | 64 ± 6.05 | 71.4 ± 1.81 | |
| MONO (%) | 15.5 ± 6.55 | 9.25 ± 4.57 | 7.8 ± 6.26 | 12.25 ± 6.13 | 7.4 ± 3.04 | |
| EOS (%) | 1.0 ± 0.00 | 1.75 ± 0.95 | 1.6 ± 0.54 | 2.75 ± 0.95 | 1.2 ± 0.44 | |
| BASO (%) | 5.75 ± 1.70 | 4.0 ± 1.15 | 6.0 ± 1.87 | 4.75 ± 1.25 | 5.2 ± 1.78 | |
|
| ||||||
| Female | WBCB (×103 cells/μL) | 5.74 ± 1.83 | 7.43 ± 1.00 | 6.82 ± 1.26 | 6.64 ± 2.10 | 6.57 ± 1.20 |
| RBC (×106 cells/μL) | 8.0 ± 0.44 | 7.91 ± 0.20 | 8.0 ± 1.59 | 8.1 ± 0.42 | 8.2 ± 0.37 | |
| Mean HGB (g/dL) | 14.35 ± 0.75 | 14.4 ± 0.47 | 14.88 ± 2.3 | 14.44 ± 0.75 | 14.58 ± 0.78 | |
| HCT (%) | 49.0 ± 3.57 | 49.66 ± 1.63 | 47.83 ± 9.57 | 47.8 ± 2.16 | 48.6 ± 2.50 | |
| MCV (fL) | 60.83 ± 1.83 | 62.66 ± 1.03 | 59.66 ± 2.73 | 59.0 ± 2.00 | 58.8 ± 0.83 | |
| MCH (pg) | 17.5 ± 0.54 | 17.83 ± 0.40 | 18.5 ± 1.22 | 17.4 ± 0.54 | 17.0 ± 0.00 | |
| MCHC (g/dL) | 28.66 ± 0.51 | 28.0 ± 0.00 | 31.0 ± 2.0 | 29.8 ± 0.44 | 29.2 ± 0.44 | |
| PLT (×103 cells/μL) | 679 ± 125.95 | 767.16 ± 49.83 | 684.16 ± 71.19 | 768.8 ± 109.26 | 822.4 ± 231.08 | |
| NEUT (%) | 17.16 ± 2.85 | 21.0 ± 5.25 | 17.33 ± 6.91 | 12.6 ± 8.29 | 17.6 ± 5.12 | |
| LYM (%) | 67.0 ± 6.606 | 66.0 ± 7.29 | 72.66 ± 8.64 | 73.4 ± 9.23 | 71.0 ± 4.47 | |
| MONO (%) | 8.16 ± 3.81 | 7.0 ± 2.52 | 7.0 ± 2.60 | 10.2 ± 0.54 | 7.4 ± 4.15 | |
| EOS (%) | 1.5 ± 0.54 | 1.0 ± 0.00 | 1.0 ± 0.00 | 1.6 ± 0.54 | 1.0 ± 0.00 | |
| BASO (%) | 6.33 ± 2.5 | 5.16 ± 1.72 | 2.0 ± 0.63 | 2.2 ± 0.83 | 3.0 ± 0.70 | |
Each value represents the mean ± standard deviation (n = 6). One-way ANOVA test (P > 0.05) followed by Dunnett's test.