TABLE 2.

Compartmental pharmacokinetic parameters of liposomal nystatin in plasma after multiple dosing over 14 days^a

Drug dose (mg/kg · day)	Cmaxb (μg/ml)	Cmin (μg/ml)	AUC0–24b (μg · h/ml)	VD (liters/kg)	VDc (liters/kg)	VDp (liters/kg)	CLtc (liters/kg · h)	CLd (liters/kg · h)	t1/2α (h)	t1/2βd (h)
2	12.86 ± 1.34	0.00 ± 0.00	11.15 ±  1.23	0.249 ± 0.039	0.123 ± 0.011	0.126 ± 0.030	0.168 ± 0.019	0.272 ± 0.077	0.141 ± 0.013	1.200 ± 0.054
4	24.65 ± 2.10	0.00 ± 0.00	32.00 ±  2.25	0.230 ± 0.024	0.137 ± 0.011	0.092 ± 0.012	0.118 ± 0.008	0.205 ± 0.043	0.182 ± 0.045	1.520 ± 0.189
6	50.40 ± 3.79	0.00 ± 0.00	88.20 ± 14.06	0.159 ± 0.017	0.101 ± 0.008	0.057 ± 0.008	0.071 ± 0.013	0.186 ± 0.004	0.128 ± 0.013	1.700 ± 0.097

^aAll values are expressed as means ± standard errors of the means. C_min, plasma concentration at the end of the dosing interval. 

^bP < 0.001 by ANOVA. 

^cP = 0.005 by ANOVA. 

^dP = 0.03 by ANOVA.