TABLE 3.
Tissue levels after daily dosing with liposomal nystatin over 15 daysa
| Tissue | Level of drug at the indicated drug dose [mg/kg · day]
|
||
|---|---|---|---|
| 2.0 | 4.0 | 6.0 | |
| Lung (μg/g) | 20.84 ± 4.28 (1.631) | 32.83 ± 10.09 (0.911) | 72.84 ± 10.78 (0.757) |
| Liver (μg/g) | 13.21 ± 2.17 (1.034) | 18.52 ± 0.54 (0.514) | 41.26 ± 2.32 (0.429) |
| Spleen (μg/g) | 6.95 ± 1.07 (0.544) | 17.11 ± 1.38 (0.475) | 46.57 ± 3.07 (0.484) |
| Kidney (μg/g) | 1.79 ± 0.19 (0.140) | 5.18 ± 0.43 (0.143) | 22.85 ± 4.22 (0.237) |
| Bone marrow (μg/g) | 1.04 ± 0.19 (0.081) | 2.49 ± 0.36 (0.069) | 7.46 ± 0.76 (0.077) |
| Skeletal muscle (μg/g) | 0.95 ± 0.01 (0.074) | 1.17 ± 0.04 (0.032) | 1.98 ± 0.17 (0.020) |
| Perirenal fat (μg/g) | 0.33 ± 0.02 (0.025) | 0.97 ± 0.19 (0.026) | 2.75 ± 0.33 (0.028) |
| Bile (μg/ml) | 3.26 ± 1.67 (0.255) | 1.73 ± 0.20 (0.048) | 17.30 ± 4.02 (0.179) |
| Urine (μg/ml) | 14.52 ± 4.04 (1.137) | 19.80 ± 4.83 (0.550) | 24.50 ± 7.99 (0.254) |
| Brain (μg/g) | <LLQ | 0.21 ± 0.02 (0.005) | 0.85 ± 0.14 (0.008) |
| CSF (μg/ml) | <LLQ | <LLQ | <LLQ |
| Choroid (μg/g) | 3.11 ± 0.61 (0.243) | 7.65 ± 2.29 (0.212) | 12.51 ± 3.9 (0.130) |
| Aqueous humor (μg/ml) | 0.20 ± 0.00 (0.015) | 0.34 ± 0.06 (0.009) | 0.49 ± 0.07 (0.005) |
| Vitreous humor (μg/ml) | <LLQ | <LLQ | <LLQ |
| Plasma (μg/ml) | 6.09 ± 0.86 | 15.57 ± 1.11 | 34.74 ± 3.74 |
a
All values are expressed as means ± standard errors of the means. Values in parentheses are ratios of mean tissue levels to mean plasma AUC0–24 after multiple dosing. For comparison, concurrent plasma levels are listed at the bottom of the table.