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Novel upcoming strategies to reverse bCSC drug resistance. (A) Cartoon structure of a nanoparticle-based drug carrier encapsulated with multiple chemotherapeutic drugs targeting bCSC antigens. (B) α- or β-emitting radionuclide conjugated with monoclonal antibody targeting breast CSC-specific antigens. (C) Design of oncolytic viral particles targeting tumor cells. (D) Cartoon representation of chimeric antigen receptor (CAR-T therapy) against CSC surface antigens.
