Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 13;36(4):913–922. doi: 10.1038/s41375-021-01425-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — A Kaplan–Meier curve of overall survival according to treatment (median OS: 10.9 months, 95% CI: 9.7–11.6 with IC and 9.2 months, 95% CI: 8.3–10.2 with HMAs). B Kaplan–Meier curve of relapse free survival according to treatment (median RFS: 11.5 months, 95% CI: 10.5–12.7 with IC and 11.0 months, 95% CI: 9.7–12.9 with HMAs). C Royston and Parmar adjusted* hazard ratio for overall survival in HMA vs. IC for each month from diagnosis. Before 1.5 months of follow-up, patients treated with HMAs had a significantly lower risk of death compared to IC patients. Between 1.5 months and 4.0 months of follow-up, there was no significant difference in survival between HMAs and IC patients. From 4.0 months of follow-up, patients treated with HMAs had a significantly higher risk of death compared to IC patients. Interaction between treatment (HMAs vs. IC) and age (< vs ≥75 y), performance status (≤ vs >1), cytogenetic risk (favorable vs. intermediate vs. adverse) or NPM1 mutation (yes vs. no) was not significant, showing that the effect of HMAs vs. IC was not significantly different according to age, performance status, cytogenetic risk and NPM1 mutation. Thus, there is no indication to stratify the analysis on age, performance status, cytogenetic risk and NPM1 mutation (Figure C was the same according to age (< vs. ≥75 y), performance status (≤ vs. >1), cytogenetic risk (favorable vs. intermediate vs. adverse) or NPM1 mutation (yes vs. no)). *Adjusted for age ≥75 y, performance status > 1, white blood cell count at diagnosis >30 giga per liter, cytogenetic risk, secondary vs de novo AML and NPM1 mutation. D Royston and Parmar adjusted* hazard ratio for relapse-free survival in HMAs vs. IC for each month from CR/CRi. Before 3 months of follow-up, patients treated with HMAs had a significantly lower risk of relapse or death compared to IC patients. Between 3 months and 8.5 months from CR/CRi, there was no significant difference between HMAs and IC patients. Beyond 8.5 months from CR/CRi, patients treated with HMA had a significantly higher risk of relapse or death compared to IC patients. Interaction between treatment (HMAs vs. IC) and age (< vs. ≥75 y), performance status (≤ vs. >1), cytogenetic risk (favorable/intermediate vs. adverse) or NPM1 mutation (yes vs. no) was not significant, showing that the effect of HMAs vs. IC was not significantly different according to age, performance status, cytogenetic risk and NPM1 mutation. Thus, there is no indication to stratify the analysis on age, performance status, cytogenetic risk and NPM1 mutation (Figure D was the same according to age (< vs. ≥75 y), performance status (≤ vs. > 1), cytogenetic risk (favorable/intermediate vs. adverse) or NPM1 mutation (yes vs. no)). *Adjusted for performance status >1, white blood cell count at diagnosis >30 giga per liter, cytogenetic risk, secondary vs. de novo AML, NPM1 and FLT3-ITD mutations.