Fig. 3. TET2^mut AMLs have modest hypermethylation that overlaps IDH^mut-specific DMRs.

A Mean DMR methylation across 1879 TET2^mut DMRs called vs. CD34+ cells (black points) and 188 in TET2^mut-specific DMRs (red points) in TET2 mutant samples versus all other AMLs that are wild type for IDH, TET2, and DNMT3A. B Intersection of TET2^mut-specific and IDH^mut-specific DMRs. C Aggregate methylation over IDH^mut-specific DMRs in IDH^mut and in TET2^mut AML and CD34+ cells. D Locus heatmap of mean methylation values for all IDH^mut-specific DMRs (rows), where each column is centered over the DMR with the window extending 5 kb up- and downstream the DMR center point. E Mean 5hmC (WGBS minus oxWGBS) levels in IDH^mut, TET2^mut, and IDH^wt/TET2^wt AML samples at 105,519 ChromHMM heterochromatic regions, 4586 generically hypermethylated regions (i.e., regions that were hypermethylated vs. CD34+ cells in at least two AMLs without IDH1, IDH2, or TET2 mutations), and 4541 IDH^mut-specific hypermethylated DMRs.