Fig. 1. BCP-ALL cell lines present heterogeneous sensitivity to cell death induced by BH3-mimetics.

BCP-ALL cell lines were exposed for 48 hours to increasing concentrations (2.5, 5, 25, 50, 250, 500, and 2500 nM) of (A) venetoclax, (B) S63845 or (C) A-1331852 before analysis of cell death by propidium iodide staining and flowcytometry. N = 3 independent experiments in triplicates. D–F Association of the EC₅₀ values of venetoclax, S63845 and A-1331852 of all cell lines. Spearman correlation; r, correlation coefficient; p, significance. (G) 3D scatter plot of the EC₅₀ values of the three inhibitors. The colors of the symbols represent the half maximal effective concentration (EC₅₀) values of venetoclax as indicated in the legend and the sizes indicate the EC₅₀ values of S63845. H Scatter plot of EC₅₀ values of the three BH3-mimetics with individual data points of single cell lines and medians (lines). Kruskal-Wallis test; p, significance.