Table 1.

Examples of circulating miRNAs that may serve as potential DM2 biomarkers

Biomarker	Sample	Diagnostic value	Population/ethnicity	Investigated Sex	References
miR-21	Plasma	Early detection of glucose imbalances	Participants from DIAPASON Study cohort, Italy	M and F	La Sala et al. (2019)
miR-126	Plasma	Prediction of susceptible individuals to DM2	Chinese Han	M and F	Zhang et al. (2013b)
miR-9, miR-28-3p, miR-29a, miR-30a-5p, miR-103, miR-126, miR-150, miR-223, miR-375	Plasma	Prediction of susceptible individuals to DM2	Patients from the CORDIOPREV Study, Spain	M, and F	Jiménez-Lucena et al. (2018)
hsa-miR-1249, hsa-miR-320b, hsa-miR-572	Plasma	Distinguish prediabetes and newly diagnosed DM2 from healthy individuals	Chinese Han	M and F	Yan et al. (2016)
miR-375	Plasma	Distinguish DM2 from healthy individuals	Chinese Kazak	M and F	Sun et al. (2014)
miR-148b, miR-223, miR-130a, miR-19a	Serum	The early diagnosis of DM2	Mongolia	M and F	(Yan et al. 2020)
miR-103b	Platelet	The early diagnosis of DM2	Chinese Han	M and F	Luo et al. (2015)
miR-503, miR-376a	Serum	Distinguish DM2 from obese DM2 patients	Spain	M and F pooled samples	Pescador et al. (2013)
miR-503, miR-138	Serum	Distinguish DM2 from obese DM2 patients	Spain	M and F pooled samples	Pescador et al. (2013)
miR-138, miR-376a, miR-15b	Serum	Distinguish obese patients from obese DM2, DM2, and healthy patients	Spain	M and F pooled samples	Pescador et al. (2013)

Abbreviations: DM2, diabetes mellitus type 2; M, male; F, female; DIAPASON Study, diabetes prediction and screening observational Study; CORDIOPREV Study, CORonary Diet Intervention with Olive oil and cardiovascular PREVention Study