Table 3.

Examples of circulating miRNAs that may serve for the selection of patients that will respond to particular DM2 treatment and therapy

Biomarker	Sample	Diagnostic value	Population/ethnicity	Investigated Sex	References
miR-24-3p, miR-126-3p, miR-21-5p, miR-15a-5p, miR-223-3p, miR-378-3p, miR-375-3p, miR-146-5p	Plasma	Prediction of response to GLP1-RA treatment in DM2 patients	Italy	M and F	Formichi et al. (2021)
miR-378, miR-126-3p, miR-223	Plasma	Disease staging and predicting response to sitagliptin treatment in DM2 elderly patients	Italy	M and F pooled	Catanzaro et al. (2018)
miR-29a, miR-28-3p, miR-126, miR-150, miR-145	Plasma	Selection of diet therapy to prevent DM2 development in coronary heart disease patients	Patients with cardiovascular disease from the CORDIOPREV Study, Spain	Not applicable	Jimenez-Lucena et al. (2021)

Abbreviations: DM2, diabetes mellitus type 2; M, male; F, female; GLP1-RA, glucagon-like peptide 1 receptor agonists; CORDIOPREV Study, CORonary Diet Intervention with Olive oil and cardiovascular PREVention Study