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. 2022 Mar 9;54(3):252–262. doi: 10.1038/s12276-022-00733-z

Fig. 4. Immune cell suppression ameliorates transcytosis in the retinas of mice with interphotoreceptor retinoid-binding protein (IRBP)-immunized.

Fig. 4

A Schematic diagram of the experimental schedule for the minocycline-induced microglial suppression model. B Serial images of whole-mounted retinas from minocycline-injected Cx3cr1-GFP mice with experimental autoimmune uveitis (EAU) showing decreased microglial activity and decreased PLVAP expression. C Quantification of microglial activation and PLVAP expression. D Schematic diagram of the experimental schedule for the anti-Ly6G antibody-induced neutrophil suppression model. E Serial images of whole-mounted retinas from anti-Ly6G antibody-injected LysM-GFP mice with EAU showing decreased neutrophil infiltration and induction of PLVAP expression. F Quantification of neutrophil infiltration and PLVAP expression. The insets are magnified images of PECAM and PLVAP in the outlined areas. Scale bars, 100 μm (B, E). *P < 0.05, **P < 0.01.