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. 2022 Apr 4;13:1790. doi: 10.1038/s41467-022-29286-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b Tumor growth curves for (a) hPD-L1-expressing MC38 tumors (n = 10 mice/group) or (b) B16-F10 tumors (n = 9 mice/group) treated with ALPN-202 (green line), anti-mPD-1 (orange line), a combination of ALPN-202 and anti-mPD-1 (blue), or an isotype control (black). c MC38/hPD-L1 tumors (n = 9 mice/group) treated with ALPN-202 (green), anti-mCTLA-4 formatted with either mIgG2b Fc (red) or inert Fc (orange), or combinations of ALPN-202 with each mCTLA-4 antibody (dark blue, light blue respectively). d Tumor growth curves (n = 9 mice/group) from NSG mice implanted with human E6 TCR⁺ transgenic T cells as well as human SCC152/hPD-L1 tumor cells treated with ALPN-202 either every three days for four doses (dark green; Q3Dx4) or once every seven days for three doses (light green; Q7Dx3), anti-hPD-L1 (durvalumab, orange) or Fc control (black). NSG NOD-scid IL2Rγ^null; E6 TCR, T cell receptor specific for E6 peptide. All experiments were repeated at least two times and data shown are representative. Statistical significance was determined by repeated-measures two-way ANOVA for treatment effects. For all graphs, means ± SEM are shown. Source data are provided as a Source Data file.