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. 2022 Apr 4;8:157. doi: 10.1038/s41420-022-00963-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative images at 40X magnification of low (left panel) and high (right panel) 4EBP1 immunohistochemical staining levels of selected NB samples represented on the NB TMAs. b Distribution of NB cases showing low (IRS 0–6) versus high (IRS 7–12) 4EBP1 protein expression in prognostically favorable versus unfavorable histological subtypes according to International Neuroblastoma Pathology Classification (INPC). Fisher’s exact test was used to calculate significance. *P < 0.05.