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. 2022 Apr 4;5:306. doi: 10.1038/s42003-022-03243-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Bayesian network constructed for the MPN dataset (μ = 5, ϵ = 3) along with b the heatmap for the MPL family. The heatmap plots presence (red) or absence (blue) of driver events for the three members of the family (CALR, JAK2 and MPL) on the y-axis against patients on the x-axis. The heatmap, thus provides a visual aid in establishing the type of relation between these genes in the dataset. The BN captures the mutual exclusivity relationship of the three major players accounting for the majority of cases: CALR, JAK2 and MPL.