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. 2022 Apr 4;12:5606. doi: 10.1038/s41598-022-08998-0

Table 1.

Characteristics of adult cohorts included in the primary meta-analysis.

NTR adults ALSPAC adults
N = 2682 N = 1232
LH RH LH RH
N 324 (12%) 2358 (88%) 99 (8%) 1133 (92%)
Age at blood sampling 34.3 (11.2) 36.8 (12.9) 49.1 (5.9) 49.0 (5.5)
Sex
Males 119 (37%) 783 (33%) 31 (31%) 333 (29%)
Females 205 (63%) 1575 (67%) 68 (69%) 800 (71%)
Multiples 315 (97.2%) 2171 (92%) 0 0
BMI 24.2 (3.7) 24.2 (3.9) 25.80 (4.3) 26.71 (4.7)
Smoking (current) 65 (20%) 486 (21%) 37 (37%) 424 (37%)
Cell proportion Neutrophils B lymphocytes
52.8 (8.7) 52.4 (9.2) 10.8 (4.3) 10.4 (4)
Eosinophils CD4T
3.1 (1.9) 3.1 (2.3) 18.4 (7.2) 18 (6.6)
Monocytes CD8T
8.4 (2.2) 8.4 (2.4) 2.2 (3.8) 1.9 (3.1)
Natural killer cells
21.9 (6.5) 20.7 (5.7)
Granulocytes
45.5 (14.7) 47.9 (12.4)
Monocytes
7.5 (3.4) 7.4 (3.5)

NTR Netherlands Twin Register, ALSPAC Avon Longitudinal Study of Parents and Children, LH left-handed, RH right-handed.

Whole blood DNA methylation (Illumina 450 k). Numbers in EWAS basic models are reported.

Values are presented as mean (standard deviation (SD)) or n (%).

Current smokers in ALSPAC were defined as those with cg05575921 methylation below 0.82 (see “Methods”section).