Table 1.
Characteristics of adult cohorts included in the primary meta-analysis.
| NTR adults | ALSPAC adults | |||
|---|---|---|---|---|
| N = 2682 | N = 1232 | |||
| LH | RH | LH | RH | |
| N | 324 (12%) | 2358 (88%) | 99 (8%) | 1133 (92%) |
| Age at blood sampling | 34.3 (11.2) | 36.8 (12.9) | 49.1 (5.9) | 49.0 (5.5) |
| Sex | ||||
| Males | 119 (37%) | 783 (33%) | 31 (31%) | 333 (29%) |
| Females | 205 (63%) | 1575 (67%) | 68 (69%) | 800 (71%) |
| Multiples | 315 (97.2%) | 2171 (92%) | 0 | 0 |
| BMI | 24.2 (3.7) | 24.2 (3.9) | 25.80 (4.3) | 26.71 (4.7) |
| Smoking (current) | 65 (20%) | 486 (21%) | 37 (37%) | 424 (37%) |
| Cell proportion | Neutrophils | B lymphocytes | ||
| 52.8 (8.7) | 52.4 (9.2) | 10.8 (4.3) | 10.4 (4) | |
| Eosinophils | CD4T | |||
| 3.1 (1.9) | 3.1 (2.3) | 18.4 (7.2) | 18 (6.6) | |
| Monocytes | CD8T | |||
| 8.4 (2.2) | 8.4 (2.4) | 2.2 (3.8) | 1.9 (3.1) | |
| Natural killer cells | ||||
| 21.9 (6.5) | 20.7 (5.7) | |||
| Granulocytes | ||||
| 45.5 (14.7) | 47.9 (12.4) | |||
| Monocytes | ||||
| 7.5 (3.4) | 7.4 (3.5) | |||
NTR Netherlands Twin Register, ALSPAC Avon Longitudinal Study of Parents and Children, LH left-handed, RH right-handed.
Whole blood DNA methylation (Illumina 450 k). Numbers in EWAS basic models are reported.
Values are presented as mean (standard deviation (SD)) or n (%).
Current smokers in ALSPAC were defined as those with cg05575921 methylation below 0.82 (see “Methods”section).