Table 2.
Characteristics of the datasets included in secondary analyses.
| ALSPAC offspring (longitudinal) | NTR children | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| at birth N = 703 | 7 years old N = 757 | 17 years old N = 759 | 24 years old N = 442 | N = 946 | ||||||
| LH | RH | LH | RH | LH | RH | LH | RH | LH | RH | |
| N | 60 (8.5%) | 643 (91.5%) | 68 (9%) | 689 (91%) | 69 (9%) | 690 (91%) | 37 (8.4%) | 405 (91.6%) | 139(15%) | 807(85%) |
| Age at blood sampling | 7.43 (0.1) | 7.4 (0.1) | 16.9 (1.1) | 17.1 (1.0) | 24.3 (0.7) | 24.3 (0.7) | 9.58(1.78) | 9.56(1.86) | ||
| Sex | ||||||||||
| Males | 32 (53.3%) | 302 (47%) | 36 (52.9%) | 332 (48.2%) | 36 (52.2%) | 321 (46.5%) | 16 (43.2%) | 173 (42.7%) | 71 (51%) | 412 (51%) |
| Females | 28 (46.7%) | 341 (53%) | 32 (47.1%) | 357 (51.8%) | 33 (47.8%) | 369 (53.5%) | 21 (56.8%) | 232 (57.3%) | 68 (49%) | 395 (49%) |
| Gestational age | 39.6 (1.5) | 39.6 (1.4) | 39.6 (1.4) | 39.6 (1.6) | 35.51(2.83) | 35.93(2.52) | ||||
| Birth weight | 3567.8 (434.4) | 3477.3 (493.6) | 3583 (445.4) | 3481 (493.3) | 2369 (585.2) | 2407 (533.5) | ||||
| Maternal smoking during pregnancy | 9 (15.2%) | 74 (11.6%) | 10 (14.9%) | 81 (11.8%) | 14(11%) | 56(7%) | ||||
| BMI | 22.5 (3.6) | 22.5 (3.6) | 24.2 (3.6) | 24.4 (4.5) | ||||||
| Smoking (current) | 20 (29.4%) | 161 (23.6%) | 9 (24.3%) | 131 (33%) | ||||||
NTR Netherlands Twin Register (buccal cell DNA methylation); ALSPAC Avon Longitudinal Study of Parents and Children (cord blood and whole blood DNA methylation); LH left-handed; RH right-handed; BMI body mass index.
Numbers in EWAS basic models are reported.
Values are presented as mean (SD) or n (%).
Current smokers in ALSPAC were defined as those with cg05575921 methylation below 0.82 (see “Methods”section).