Table 3.

Top differentially methylated positions from EWAS meta-analysis of left-handedness.

CpG	CHR	Positiona	Gene	Location	β	SE	P	FDR	Direction
cg22804475	8	20,054,597	ATP6V1B2	TSS200	− 0.0007	0.0002	1.28 × 10–06	0.197	–
cg09239756	12	106,642,360	CKAP4	TSS1500	− 0.0032	0.0007	1.82 × 10–06	0.197	–
cg22541911	12	51,785,465	GALNT6	TSS1500	− 0.0010	0.0002	1.90 × 10–06	0.197	–
cg13719901	3	46,608,139	LRRC2	5′UTR; TSS200	0.0081	0.0017	2.60 × 10–06	0.197	+  +
cg02850812	13	46,961,666	C13orf18	TSS200	− 0.0014	0.0003	2.62 × 10–06	0.197	–
cg16852837	18	51,750,955	MBD2	1st Exon; 5′UTR	− 0.0006	0.0001	3.28 × 10–06	0.205	–
cg09893588	20	61,340,109	NTSR1	TSS200	− 0.0011	0.0003	9.12 × 10–06	0.256	–
cg12402132	12	121,148,554	UNC119B	Gene body	− 0.0009	0.0002	9.54 × 10–06	0.256	–

β is the regression coefficient for left-handedness in EWAS meta-analysis adjusted model that included N_{NTR adults} = 2663 and N_{ALSPAC adults} = 1058.

CpGs with uncorrected P-value < 1.0 × 10^–5 are presented.

CHR chromosome; SE standard error; FDR false discovery rate; TSS200 200 base pairs upstream of transcription start site;TSS1500 1500 base pairs upstream of transcription start site; 5′UTR 5′ untranslated region; +  +, positive direction of effect in each cohort; –, negative direction of effect in each cohort.

^aGenome build Hg19 (build 37). See additional information on CpGs in Supplementary Table 12.