Skip to main content
. 2022 Apr 4;13(4):302. doi: 10.1038/s41419-022-04758-0

Fig. 7. Schematic representation of the RAGE–TXNIP pathway implicated in microglia dysfunction in an AD contest.

Fig. 7

RAGE–TXNIP drives Aβ from the cell surface to mitochondria, leading to Drp1 oligomerization and translocation to mitochondria. These events lead to NLRP3 complex formation, resulting in caspase-1 activation, which in turn results in IL-1β secretion and GSDMD cleavage, producing CTD and PFD. The Pore Forming Domain (PFD) of cleaved GSDM assembles at the plasma membrane, inducing pyroptosis. RAGE receptor for advanced glycation endproducts. TXNIP thioredoxin-interacting protein. AD Alzheimer’s disease. Amyloid-beta peptide. Drp1 Dynamin-related protein 1, NLRP3 NOD-like receptor family, pyrin domain containing 3. Pro-IL-1β pro-interleukin 1 beta, IL-1β interleukin 1 beta, GSDMD gasdermin D, CTD C terminal domain (of GSDMD), PFD pore-forming domain.