Fig. 1. Olaparib and onalespib combination in ovarian PDX models.

NSG mice bearing luciferized PDXs were treated with vehicle, olaparib (100 mg/kg, daily), onalespib (45 mg/kg 2×/week) or their combination for 4 weeks with n = 1 per group per model. Tumour growth was monitored by weekly bioluminescence imaging. Fold change in the bioluminescence from day 0 is shown. Inlay bar graph shows CA125 in mouse plasma at the end of treatment performed in triplicate.