Table 3.
Treatment-related toxicities that are grade 3 + or occurring in ≥ 10% of patients (n = 28).
| Toxicity | Maximum grade | ||
|---|---|---|---|
| 1–2 | 3 | 4 | |
| Diarrhoea | 21 (75%) [3–3-3–5-3–4]a | 1 (4%) DL3a | — |
| Nausea | 18 (64%) [1–2–4–6-3–2] | 1 (4%) DL0 | — |
| Anaemia | 13 (46%) [2–3–2–4-1–1] | 5 (18%) 2 DL3, 3 DL3a | — |
| Thrombocytopenia/platelet count decrease | 10 (36%) [0–3-1–3-0–3] | 2 (7%) DL3, DL3a | — |
| Fatigue | 12 (43%) [1–3–3–2-1–2] | — | — |
| Vomiting | 8 (29%) [1–1–3–2-1-0] | 1 (4%) DL0 | — |
| Abdominal pain | 4 (14%) [1–1-0-0-2–0] | 1 (4%) DL2 | — |
| Anorexia | 5 (18%) [1–1-1-0-1–1] | — | — |
| Neutrophil count decreased | 3 (11%) [0-0-1–1-0-1] | — | 1 (4%) DL3a |
| Lymphocyte count decreased | 3 (11%) [0-0-0-1–1-1] | 1 (4%) DL3a | — |
| Floaters | 4 (14%) [0-1-0-1-0-2] | — | — |
| Dysgeusia | 4 (14%) [0-1-0-1-0-2] | — | — |
aCorresponding to DL0-DL1-DL2-DL3-DL2a-DL3a, respectively.