TABLE 1.

Summary of results for amprenavir pharmacokinetic parameters

Parameter	GLSM (arithmetic mean CVb) for:		Treatment 3 GLSM/treatment 1 GLSM ratio (90% CI)
	Treatment 1c	Treatment 3d
AUCss (h · μg/ml)	27.40 (29.08, 26%)	32.28 (32.98, 24%)	1.18 (1.08–1.29)
Cmax,ss (μg/ml)	8.42 (8.98, 26%)	9.65 (10.10, 26%)	1.15 (1.01–1.31)
Cmin,ss (μg/ml)	0.38 (0.41, 45%)	0.53 (0.53, 38%)	1.39 (1.31–1.47)
CL/F (ml/min)	730 (754, 38%)	619 (649, 30%)	0.85 (0.78–0.93)
Tmax,ss (h)e	1.14 (1.25, 53%)	1.38 (1.34, 38%)	0.19 (0.00–0.39)

^aGLSM, geometric least-squares mean. 

^bCV, coefficient of variation. 

^cAmprenavir, 1,200 mg twice a day. 

^dAmprenavir, 1,200 mg twice a day, plus clarithromycin, 500 mg twice a day. 

^eMedian and median difference.