TABLE 3.

Geometric least-squares means for 14-(R)-hydroxyclarithromycin pharmacokinetic parameters

Parameter	Geometric least-squares mean for:		Treatment 3/treatment 2 ratio (90% CI)
	Treatment 2a	Treatment 3b
AUCss (h · μg/ml)	7.40	4.83	0.65 (0.59–0.72)
Cmax,ss (μg/ml)	0.81	0.55	0.68 (0.59–0.79)
Cmin,ss (μg/ml)	0.44	0.43	0.96 (0.78–1.17)
AUC14-OH/AUCCLARc	0.38	0.24	0.63 (0.43–0.84)
Tmax,ss (h)d	3.00	5.25	2.00 (0.25–4.25)
CLR (ml/min)	134	171	1.28 (1.12–1.46)
% Dosec	11.70	9.83	0.84 (0.76–0.92)

^aConsists of 500 mg of clarithromycin twice a day. 

^bConsists of 1,200 mg of amprenavir twice a day plus 500 mg of clarithromycin twice a day. 

^cLeast-squares mean and least-squares mean ratio. 

^dMedian and median difference.