Table 2.

MIC of antibiotics for E. coli and P. aeruginosa in the presence of CPP-PNAs.

E. coli
Antibiotics	KFF-NC MIC (μg/mL)	KFF-bamB MIC (μg/mL)	KFF-tolC MIC (μg/mL)	KFF-bamB KFF-tolC MIC (μg/mL)a
Vancomycin	100	> 200	100	100
Actinomycin D	50	25	50	< 6.3
Novobiocin	12.5	0.8	12.5	< 0.4
Fusidic acid	50	12.5	50	< 0.4
5-Ketoclomazone	> 250	> 250	125	62.5

P. aeruginosa
Antibiotics	Control (no CPP-PNA) MIC (μg/mL)	RXR-NC MIC (μg/mL)	RXR-bamB MIC (μg/mL)	RXR-oprM MIC (μg/mL)	RXR-bamB RXR-oprM MIC (μg/mL)b
Vancomycin	1024	1024	256	512	256
Erythromycin	128	128	32	64	< 16
Carbenicillin	64	64	8	32	< 4

CPP-PNAs were added at the concentration of 5 and 3 μM for E. coli and P. aeruginosa, respectively.

^aIn the presence of both CPP-PNAs, equimolar KFF-bamB and KFF-tolC were mixed.

^bIn the presence of both CPP-PNAs, equimolar RXR-bamB and RXR-oprM were mixed.