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. 2022 Apr 4;10:12. doi: 10.1186/s40635-022-00439-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Primary and secondary tissue oxygen delivery outcomes. A Time to treat analysis of composite tissue oxygen delivery target (muscle StO₂ ≥ 50% and arterial lactate ≤ 2 mM). B Regional tissue oxygen saturation-muscle. C Arterial lactate. D Venous oxygen saturation. E Regional tissue oxygen saturation-brain. F Arterial base excess. Shaded areas represent levels outside the normal range or treatment target. Data shown as mean or geometric mean according to normality test, with 95% confidence intervals. Mixed model ANOVA with Tukey correction for multiple comparisons; *p < 0.05