TABLE 1.
Volume of ELF and AC counts at six time periods following drug administration
| Characteristic | 4 h | 5 h | 7 h | 12 h | 24 h | 48 h |
|---|---|---|---|---|---|---|
| Total cell count in BAL fluida (cells/liter) | 1.31 × 108 ± 7.57 × 107 | 1.72 × 108 ± 1.18 × 108 | 1.41 × 108 ± 1.71 × 108 | 9.94 × 107 ± 1.60 × 107 | 8.52 × 107 ± 2.67 × 107 | 9.30 × 107 ± 6.62 × 107 |
| Neutrophilsa (%) | 1.0 ± 1.2 | 1.6 ± 0.9 | 0.8 ± 0.8 | 0.8 ± 0.8 | 1.0 ± 1.0 | 1.4 ± 1.1 |
| Lymphocytes (%) | 11.2 ± 8.6 | 11.4 ± 6.8 | 22.6 ± 10.8 | 8.8 ± 5.7 | 9.0 ± 8.6 | 18.4 ± 10.3 |
| Monocytes/macrophages (%) | 86.0 ± 11.8 | 84.6 ± 7.6 | 76.2 ± 11.7 | 84.8 ± 9.5 | 89.6 ± 9.0 | 70.8 ± 21.7 |
| Eosinophils (%) | 0.8 ± 1.8 | 1.4 ± 2.2 | 0.4 ± 0.9 | 2.0 ± 4.5 | 0.4 ± 0.5 | 0.4 ± 0.5 |
| Degenerated cells (%) | 1.0 ± 2.2 | 1.0 ± 2.2 | 0.0 ± 0.0 | 3.6 ± 8.0 | 0.0 ± 0.0 | 9.0 ± 11.6 |
| ELF vola (ml) | 0.82 ± 0.63 | 1.00 ± 0.35 | 1.21 ± 0.57 | 0.98 ± 0.39 | 1.13 ± 1.19 | 0.81 ± 0.48 |
| BAL volb (ml) | 71 ± 8.2 | 79.8 ± 7.4 | 77 ± 7.2 | 77.6 ± 3.0 | 78.2 ± 11.7 | 79.8 ± 7.5 |
a
The differences in AC count, differential cell count, or ELF volume among the six groups were not significant (P > 0.05).
b
Mean ± SD for pooled volume of BAL fluid recovered.