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. 2022 Mar 22;10:847573. doi: 10.3389/fchem.2022.847573

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Copyright © 2022 Mokhtar, Khattab, Elkhodairy, Teleb, Bekhit, Elzoghby and Sallam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In vitro release study of EXE from free EXE, EXE\LCNPs F2, and MTX/Lf\EXE\LCNPs F4 at physiological pH 7.4 (n = 3). (B) In vitro release study of MTX from free MTX and MTX/Lf\EXE\LCNPs F4 at physiological pH 7.4 (n = 3).