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. 2022 Mar 22;13:858215. doi: 10.3389/fphar.2022.858215

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Copyright © 2022 Keller, Yorgan, Rading, Schinke and Karsak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone formation and mineralization were similar between genotypes and not affected by JWH133. (A) Mineral apposition rate (MAR) of p62 KO and WT mice treated with JWH133 was comparable. (B) Mineral surface per bone surface (MS/BS) showed no difference by comparing for genotype and treatment. (C) Bone formation rate per bone surface (BRF/BS) showed no effect of treatment and was comparable between genotypes. Male mice were aged 3 months by the beginning of the experiment and were treated for 5 days with vehicle or JWH133. Data were analyzed by using ordinary two-way ANOVA and Bonferroni adjusted pnvalues, *p < 0.05, **p < 0.01, ***p < 0.001. All error bars show mean ± SEM. Squares and circles represent individual data points. WT vehicle N = 7, KO vehicle N = 8, WT JWH133 N = 8, KO JWH133 N = 8.