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. 2022 Mar 22;13:858215. doi: 10.3389/fphar.2022.858215

FIGURE 5.

FIGURE 5

JWH133 treatment increased the number and surface of osteoblasts and osteoclasts in p62 KO mice. (A) Number of osteoblasts per bone perimeter (N.Ob/B.Pm) was weakly reduced in p62 KO mice compared to WT mice. The treatment was only effective in p62 KO mice as it increased the number of osteoblasts. (B) Osteoblast surface per bone surface (Ob.S/BS) was mildly reduced in p62 KO mice compared to WT mice. The treatment was only effective in p62 KO mice as it increased the surface of osteoblasts. (C) Number of osteoclasts per bone perimeter (N.Oc/B.Pm) was similar between genotypes but was significantly increased in p62 KO mice after JWH133 treatment. (D) Surface of osteoclasts per bone surface (Oc.S./BS) was similar between genotypes but was significantly increased in p62 KO mice after JWH133 treatment. Male mice were aged 3 months by the beginning of the experiment and were treated for 5 days with vehicle or JWH133. Data were analyzed by using ordinary two-way ANOVA and Bonferroni adjusted p values, *p < 0.05, **p < 0.01, ***p < 0.001. All error bars show mean ± SEM. Squares and circles represent individual data points. WT vehicle N = 7, KO vehicle N = 8, WT JWH133 N = 8, KO JWH133 N = 8.