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. 2022 Mar 22;13:858215. doi: 10.3389/fphar.2022.858215

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Copyright © 2022 Keller, Yorgan, Rading, Schinke and Karsak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aged mice did not respond with detectable changes in femoral trabecular and cortical bone (μCT) after a prolonged treatment duration with JWH133. (A) Male mice were aged 6 months by the beginning of the experiment. Body weight of p62 KO animals was significantly increased compared to WT mice at the beginning of the experiment. (B) Bone volume per tissue volume (BV/TV) was similar between WT and p62 KO mice and showed no effect of treatment. (C) Trabecular number (Tb.N) was comparable between genotypes without an effect of treatment. (D) Trabecular spacing (Tb.Sp) showed no difference between genotype or treatment. (E) Trabecular thickness (Tb.Th) was comparable for genotype and treatment. (F) Tissue mineral density (TMD) of the femur was not influenced by the treatment and showed no difference between genotypes. (G) Cortical thickness (Ct.Th) was lower in p62 KO mice leading to a significant effect of genotype. (H) Cortical porosity (Ct.Po) and (I) tissue mineral density (Ct.TMD) of cortical bone were similar between genotypes and not influenced by the treatment with JWH133. Data were analyzed by using ordinary two-way ANOVA and Bonferroni adjusted p values, *p < 0.05, **p < 0.01, ***p < 0.001. All error bars show mean ± SEM. Squares and circles represent individual data points. WT vehicle N = 8, KO vehicle N = 9, WT JWH133 N = 8, KO JWH133 N = 8.