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. 2022 Mar 22;13:858215. doi: 10.3389/fphar.2022.858215

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Copyright © 2022 Keller, Yorgan, Rading, Schinke and Karsak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prolonged treatment with JWH133 increased tissue mineral density in the vertebrae of aged mice. (A) Representative image of the vertebral trabecular bone compartment (L5) analyzed by μCT of p62 KO and WT mice treated with vehicle or JWH133. (B) Bone volume per tissue volume (BV/TV) was similar between WT and p62 KO mice showed no effect of treatment. (C) Trabecular number (Tb.N) was comparable between genotypes showed no effect of treatment. (D) Trabecular spacing (Tb.Sp) showed no difference between genotype or treatment. (E) Trabecular thickness (Tb.Th) was not different. (F) Tissue mineral density (TMD) was significantly influenced by the treatment with JWH133 and affected p62 KO and WT mice. Data were analyzed by using ordinary two-way ANOVA and Bonferroni adjusted p values, *p < 0.05, **p < 0.01, ***p < 0.001. All error bars show mean ± SEM. Squares and circles represent individual data points. WT vehicle N = 7, KO vehicle N = 9, WT JWH133N = 8, KO JWH133 N = 8.