. 2022 Mar 5;298(4):101800. doi: 10.1016/j.jbc.2022.101800

Table 1.

Effect of MCTs, TAUT substrates/inhibitors on [³H]taurine uptake by MCT7

Classification	MCT7-mediated uptake
Classification	Substrates/inhibitors	(% of control)
	Control	100 ± 5
TAUT	β-alanine	102 ± 14
	GABA	108 ± 24
	homocysteic acid	25.6 ± 13.7^a
PAT1	L-alanine	102 ± 17
PAT1	L-proline	108 ± 26
Amino acids	L-asparagine	99.3 ± 7.5
	L-asparatate	66.7 ± 8.7^b
	L-glutamate	32.7 ± 3.3^a
	L-phenylalanine	102 ± 9.4
MCTs	lactate	75.2 ± 6.6^b
	butyrate	30.1 ± 15.3^a
	β-hydroxybuytyrate	41.4 ± 12.3^a
	creatine	98.5 ± 20.1
	L-carnitine	74.4 ± 9.2^b
Ketone body	acetoacetate	73.9 ± 14.6^b
Ketone body	acetone	113 ± 13

HEK293T cells were transfected with MCT7/pEGFP-C1 or empty-vector. Uptake of [³H]taurine by the cells was measured by Na⁺-free buffer for 30 min. The substrates/inhibitors of transporters were used at 50 mM except for homocysteic acid at 30 mM. MCT7-mediated uptake was calculated by subtracting the uptake amount of mock-transfected cells from that of MCT7-transfected cells. Each point represents the mean ± S.D. (n = 6).

p < 0.01

p < 0.05, compared with the corresponding control by one-way ANOVA with Tukey's multiple comparisons test.