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Mechanism of ferritinophagy. NCOA4 mediated ferritinophagy transports intracellular ferritin to autophagy lysosome for degradation and release free iron. By overloading intracellular iron, ROS production in the labile iron pool increases, so as to increase the sensitivity of cells to ferroptosis. NCOA4, nuclear receptor co-activator 4; ROS, reactive oxygen species.
