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. 2022 Mar 22;12:842312. doi: 10.3389/fonc.2022.842312

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Copyright © 2022 Wei, Chen, Chen, Guo, Hong and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of Sox15 is reduced and positively correlates with prognosis in HCC as analyzed by our cohort. (A) Sox15 mRNA levels within HCC as well as paraneoplasia samples measured through RT-qPCR. (B) Quantification of Sox15 protein levels of the representative HCC and its paraneoplasia samples shown in panel (C, D) KM analysis suggested that HCC cases with reduced Sox15 levels suffered worse OS. (D) Sox15 protein levels of the indicated HCC and its paraneoplasia samples measured by Western Blot. (E) Sox15 protein levels within HCC and its paraneoplasia tissues measured by IHC. *p < 0.05, ***p < 0.001.