Table 1.
Early death or without early death events in patients with mRCC.
| Characteristic | SEER cohort (n = 6,005) | ||
|---|---|---|---|
| Early death (%) | No early death (%) | P-value | |
| All | 1,816 (30.2) | 4,189 (69.8) | |
| Age | <0.001* | ||
| ≤ 61 | 575 (31.7) | 2,052 (49.0) | |
| 62–77 | 791 (43.6) | 1,715 (40.9) | |
| ≥78 | 450 (24.8) | 422 (10.1) | |
| Sex | 0.007 | ||
| Male | 1,207 (66.5) | 2,931 (70.0) | |
| Female | 609 (33.5) | 1,258 (30.0) | |
| Race | 0.002 | ||
| White | 1,499 (82.5) | 3,438 (82.1) | |
| Black | 204 (11.2) | 397 (9.5) | |
| Others | 113 (6.2) | 354 (8.5) | |
| Histologic type | <0.001* | ||
| ccRCC | 495 (27.3) | 2,434 (58.1) | |
| pRCC | 66 (3.6) | 202 (4.8) | |
| sRCC | 129 (7.1) | 208 (5.0) | |
| chRCC | 4 (0.2) | 37 (0.9) | |
| cdRCC | 15 (0.8) | 28 (0.7) | |
| RCC | 1,107 (61.0) | 1,280 (30.6) | |
| Size | 0.424 | ||
| ≤ 82 | 843 (46.4) | 1,929 (46.0) | |
| 83–140 | 776 (42.7) | 1,846 (44.1) | |
| ≥141 | 197 (10.8) | 414 (9.9) | |
| Grade | <0.001* | ||
| GI-II | 100 (5.5) | 582 (13.9) | |
| GIII-IV | 423 (23.3) | 1,777 (42.4) | |
| Unknown | 1,293 (71.2) | 1,830 (43.7) | |
| T -stage | <0.001* | ||
| T1 | 392 (21.6) | 797 (19.0) | |
| T2 | 391 (21.5) | 840 (20.1) | |
| T3 | 559 (30.8) | 1,979 (47.2) | |
| T4 | 250 (13.8) | 355 (8.5) | |
| TX | 224 (12.3) | 218 (5.2) | |
| N -stage | <0.001* | ||
| N0 | 1,033 (56.9) | 2,901 (69.3) | |
| N1 | 432 (23.8) | 707 (16.9) | |
| N2 | 351 (19.3) | 581 (13.9) | |
| Bone metastasis | 0.010 | ||
| No | 1,067 (58.8) | 2,609 (62.3) | |
| Yes | 749 (41.2) | 1,580 (37.7) | |
| Lung metastasis | <0.001* | ||
| No | 605 (33.3) | 1,689 (40.3) | |
| Yes | 1,211 (66.7) | 2,500 (59.7) | |
| Liver metastasis | <0.001* | ||
| No | 1,256 (69.2) | 3,589 (85.7) | |
| Yes | 560 (30.8) | 600 (14.3) | |
| Brain metastasis | <0.001* | ||
| No | 1,527 (84.1) | 3,772 (90.0) | |
| Yes | 289 (15.9) | 417 (10.0) | |
| Surgery | <0.001* | ||
| No | 1,521 (83.8) | 1,862 (44.4) | |
| Yes | 295 (16.2) | 2,327 (55.6) | |
| Radiotherapy | <0.001* | ||
| No | 1,383 (76.2) | 2,837 (67.7) | |
| Yes | 433 (23.8) | 1,352 (32.3) | |
| Chemotherapy | <0.001* | ||
| No | 1,328 (73.1) | 1,590 (38.0) | |
| Yes | 488 (26.9) | 2,599 (62.0) | |
| Cause of death | <0.001* | ||
| mRCC | 1,687 (92.9) | 2,833 (67.6) | |
| Other cause | 129 (7.1) | 1,356 (32.4) | |
ccRCC, clear cell renal cell carcinoma; pRCC, papillary renal cell carcinoma; chRCC, chromophobe renal cell carcinoma; sRCC, sarcomatoid renal cell carcinoma; cdRCC, collecting duct renal cell carcinoma; RCC, renal cell carcinoma.
The bold values mean statistically significance (p < 0.01).