Table 3.
Univariate and multivariate logistic regression for identifying the risk factors for early death of mRCC.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| Age (years) | ||||||
| ≤ 61 | Ref | Ref | ||||
| 62–77 | 1.668 | 1.437–1.935 | <0.001* | 1.388 | 1.159–1.664 | <0.001* |
| ≥78 | 3.474 | 2.864–4.213 | <0.001* | 1.672 | 1.306–2.140 | <0.001* |
| Sex | ||||||
| Male | Ref | - | ||||
| Female | 1.192 | 1.036–1.372 | 0.014 | - | - | - |
| Race | ||||||
| White | Ref | Ref | ||||
| Black | 1.337 | 1.079–1.656 | 0.008 | 1.008 | 0.773–1.314 | 0.954 |
| Other | 0.660 | 0.501–0.869 | 0.003 | 0.686 | 0.490–0.960 | 0.028 |
| Histologic type | ||||||
| ccRCC | Ref | |||||
| pRCC | 1.332 | 0.910–1.950 | 0.140 | 1.202 | 0.773–1.868 | 0.414 |
| sRCC | 3.150 | 2.366–4.194 | <0.001* | 2.806 | 1.994–3.950 | <0.001* |
| chRCC | 0.350 | 0.083–1.475 | 0.153 | 0.357 | 0.075–1.693 | 0.195 |
| CDC | 3.031 | 1.504–6.112 | 0.002 | 2.910 | 1.279–6.623 | 0.010 |
| RCC | 4.371 | 3.762–5.077 | <0.001* | 1.954 | 1.616–2.362 | <0.001* |
| Size | ||||||
| ≤ 82 | Ref | - | ||||
| 83–140 | 1.017 | 0.885–1.168 | 0.816 | - | - | - |
| ≥141 | 1.143 | 0.913–1.431 | 0.245 | - | - | - |
| Grade | ||||||
| GI-II | Ref | Ref | ||||
| GIII-IV | 1.506 | 1.130–2.007 | 0.005 | 2.144 | 1.515–3.033 | <0.001* |
| Unknown | 4.360 | 3.322–5.722 | <0.001* | 1.388 | 0.996–1.935 | 0.053 |
| T -stage | ||||||
| T1 | Ref | Ref | ||||
| T2 | 0.953 | 0.776–1.170 | 0.645 | 1.087 | 0.844–1.400 | 0.519 |
| T3 | 0.612 | 0.510–0.735 | <0.001* | 1.280 | 1.001–1.636 | 0.049 |
| T4 | 1.540 | 1.210–1.959 | <0.001* | 1.739 | 1.284–2.357 | <0.001* |
| TX | 2.355 | 1.810–3.064 | <0.001* | 1.479 | 1.084–2.017 | 0.014 |
| N stage | ||||||
| N0 | Ref | Ref | ||||
| N1 | 1.717 | 1.454–2.028 | <0.001* | 1.365 | 1.110–1.680 | 0.003 |
| N2 | 1.707 | 1.423–2.047 | <0.001* | 1.850 | 1.471–2.327 | <0.001* |
| Bone metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.097 | 0.959–1.255 | 0.177 | 1.316 | 1.088–1.591 | 0.005 |
| Lung metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.300 | 1.133–1.490 | <0.001* | 1.387 | 1.163–1.653 | <0.001* |
| Liver metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 2.599 | 2.219–3.043 | <0.001* | 1.989 | 1.635–2.419 | <0.001* |
| Brain metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.685 | 1.384–2.051 | <0.001* | 2.115 | 1.618–2.765 | <0.001* |
| Surgery | ||||||
| No | Ref | Ref | ||||
| Yes | 0.146 | 0.124–0.173 | <0.001* | 0.151 | 0.116–0.198 | <0.001* |
| Radiotherapy | ||||||
| No | Ref | Ref | ||||
| Yes | 0.666 | 0.573–0.774 | <0.001* | 0.651 | 0.521–0.813 | <0.001* |
| Chemotherapy | ||||||
| No | Ref | Ref | ||||
| Yes | 0.218 | 0.189–0.252 | <0.001* | 0.175 | 0.147–0.209 | <0.001* |
ccRCC, clear cell renal cell carcinoma; pRCC, papillary renal cell carcinoma; chRCC, chromophobe renal cell carcinoma; sRCC, sarcomatoid renal cell carcinoma; cdRCC, collecting duct renal cell carcinoma; RCC, renal cell carcinoma.
The bold values mean statistically significance (p < 0.01).