Table 1. Clinical characteristics of patients.
| Variables | TPHPT (n = 158) | NPHPT (n = 122) | P value | |
|---|---|---|---|---|
| Age, yr | 59.3 ± 14.0 | 54.3 ± 13.1 | 0.002a | |
| Age < 50 yr | 33 (20.9%) | 40 (32.8%) | 0.025a | |
| Sex | 0.035a | |||
| Male | 38 (24.1%) | 17 (13.9%) | ||
| Female | 120 (75.9%) | 105 (86.1%) | ||
| BMD (n = 132, 99) | 0.008a | |||
| Normal | 15 (11.4%) | 27 (27.3%) | ||
| Osteopenia | 51 (38.6%) | 30 (30.3%) | ||
| Osteoporosis | 66 (50.0%) | 42 (42.4%) | ||
| T-score (lumbar) (n = 132, 99) | −2.4 ± 1.2 | −2.0 ± 1.3 | 0.024a | |
| Nephrolithiasis | 28 (17.7%) | 15 (12.3%) | 0.212 | |
| Bone fracture | 13 (8.2%) | 9 (7.4%) | 0.793 | |
| Preop PTH, pg/mL | 212.7 ± 219.3 | 115.9 ± 45.7 | 0.000a | |
| Preop sCa, mg/dL | 11.4 ± 1.1 | 9.9 ± 0.5 | 0.000a | |
| Preop iCa, mg/dL | 5.8 ± 0.4 | 5.4 ± 0.3 | 0.000a | |
| Preop P, mg/dL | 2.6 ± 0.5 | 2.9 ± 0.5 | 0.000a | |
| Preop 25-OH-Vit D, ng/mL | 19.3 ± 9.4 | 21.4 ± 9.2 | 0.065 | |
| 24hr urine calcium, mg/24hr | 324.3 ± 178.2 | 285.8 ± 159.9 | 0.105 | |
| eGFR, mL/min/1.73m2 | 80.4 ± 11.9 | 86.0 ± 8.2 | 0.000a | |
All continuous variables expressed as mean ± standard deviation.
TPHPT = typical primary hyperparathyroidism, NPHPT = normocalcemic primary hyperparathyroidism, BMD = bone mineral density, PTH = parathyroid hormone, sCa = serum calcium, iCa = ionized calcium, P = phosphorus, 25-OH-Vit D = 25-hydroxy-vitamin D, eGFR = estimated glomerular filtration rate.
aStatistical significance.