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. 2022 Mar 22;12:726985. doi: 10.3389/fonc.2022.726985

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Copyright © 2022 Xu, He, Xiao, Si, Shi, Liu, Tian, Ren, Wu and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of a novel sushi-IL15-PD1 CAR-NK92 cell line (SP). (A) Sequential expression cassette diagram of the chimeric antigen receptor (CAR), including signal peptide, IL-15Rα-sushi, CD8 transmembrane domain, signal transduction domain of 4-1BB and CD3ζ, 2A peptide, PD1 extracellular domain and IL-15. (B) Structure diagram of the protein expression pattern of the CAR gene. (C) Surface expression of programmed cell death 1 (PD-1), IL-15Rα, and IL-15 in SP and NK92 cells was analyzed by flow cytometry (FCM). (D) Cellular immunofluorescence detection of CAR molecules localized and expressed on SP cell membrane.