Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 22;12:726985. doi: 10.3389/fonc.2022.726985

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Xu, He, Xiao, Si, Shi, Liu, Tian, Ren, Wu and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The degranulation of SP and the targeted delivery of cytotoxic granule content were more efficient and lethal. (A) After co-culture, effector cells were collected and the changes in red fluorescence were detected by FCM, indicating the lysosome exocytosis. Morphological changes in target cells before and after co-culture were observed in bright field (B), while FITC channel for (C) quantitative assessment of lysosomes entering target cells as indicated by increased red fluorescence mean fluorescence intensity (MFI) (Cy5 channel). (D) Target cells death as indicated by green fluorescence (MFI FITC decrease). All summary data showed mean ± SEM, n = 5 different fields. **P < 0.01, ***P < 0.001.