Table 2.

Comparison of the optic radiation diffusion metrics between typically developing children (TDC) and children and adolescents with recurrent demyelinating syndromes, including patients with multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein associated disorders (MOGAD). Diffusion metrics: fibre density (FD), fibre cross-section (FC), fibre density and cross-section (FDC), axonal water fraction (AWF) and tortuosity (TORT). p-values were adjusted using false discovery rate (FDR).

Metrics	MS	MOGAD	TDC	H-statistic	p-value
FD	0.421(0.007)	0.416(0.008)	0.45(0.003)	32.9	<0.001
				−4.69	<0.001
				−4.82	<0.001
				0.21	0.8
FC	−0.026(0.019)	0.011(0.029)	0.094(0.017)	21.0	0.00003
				−3.35	0.0012
				−4.16	0.000095
				−0.466	0.64
FDC	0.419(0.012)	0.529(0.015)	0.482(0.009)	31.5	<0.001
				−4.38	0.000018
				−4.91	0.0000027
				−0.152	0.88
AWF	0.341(0.003)	0.346(0.003)	0.347(0.002)	5.73	0.056
				−0.348	0.728
				−2.32	0.06
				−1.68	0.094
TORT	2.11(0.039)	2.15(0.042)	2.39(0.017)	43.3	<0.001
				−4.84	0.0000038
				−5.95	0.0000000078
				−0.616	1