Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 22;13:847937. doi: 10.3389/fimmu.2022.847937

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhong and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

IL-17 family and signaling pathway. The IL-17 family includes six factors and five receptors. IL-17RA and IL-17RC subunits bind to IL-17A, IL-17F and IL-17AF ligands. IL-17RA and IL-17RB subunits bind to IL-17B and IL-17E ligands. The receptors of IL-17C are IL-17RA and IL-17RE. IL-17D and IL-17RD are currently unknown. They shared the common cytoplasmic motif SEFIR domain can recruit act1 and nonconserved region called SEFEX.ACT-1 can bind to TRAF family proteins. For IL-17A, TRAF6 can activate NF-κB pathway, MAPK/ap1 pathway. Act1 can also promote post-transcriptional mRNA stabilization through the transcriptional induction of TRAF2/5. In addition, The Il-17R-act1 complex binded to MEKK3 and MEK5 via TRAF4 to activate ERK5. In addition to the classic pathway, IL-17E also mediates Act1-JAK1/2-STAT3 pathway.