Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 22;13:847937. doi: 10.3389/fimmu.2022.847937

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhong and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic diagram of the involvement of IL-17A in AMD, DR, and glaucoma. In AMD, IL-17A activates NLRP3, secretes IL-1β, and induces various signaling pathways in RPE. IL-17A promotes the expression of caspase-1, caspase-3 and caspase-9 pathways from the post-transcriptional level. IL-17A disrupts the distribution of tight junctions and destroys the blood-retinal barrier. IL-17A mainly targets blood vessels in DR, inducing inflammation, vascular leakage and capillary degeneration. The cells expressing RORγt may be the main producers of IL-17A in the retina. In glaucoma, IL-17A was found to be closely related to activated microglia.