Table 3.

Cox regression analyses of the effect of the heart rate on the secondary endpoint.

HR strata, beats per min		No. of events	Hazard ratio	P value
		(% per person-year)	(95% CI)
Composite secondary endpoint
In HFpEF	≤ 60 bpm	2	Reference
(n = 17, 1.3%/person-year)	61–80 bpm	8	0.64 (0.13–3.25)	0.591
	81–110 bpm	6	1.44 (0.28–7.58)	0.664
	>110 bpm	1	4.88 (0.37–64.75)	0.230
In HmFrEF:	≤ 60 bpm	8	Reference
(n = 45, 4.4%/person-year)	61–80 bpm	21	0.50 (0.21–1.22)	0.127
	81–110 bpm	8	0.44 (0.16–1.19)	0.105
	>110 bpm	8	2.78 (0.87–8.90)	0.086
In HFrEF:	≤ 60 bpm	2	Reference
(n = 28, 4.4%/person-year)	61–80 bpm	18	1.75 (0.41–7.59)	0.453
	81–110 bpm	6	0.91 (0.18–4.64)	0.909
	>110 bpm	2	0.55 (0.07–4.22)	0.561

A multivariable Cox regression was performed with the variables listed in Table 1 without echoparameters.

CI, confidence interval; HF, heart failure; HR, heart rate; HFpEF, heart failure preserved ejection fraction; HR, heart rate; HFrEF, heart failure reduced ejection fraction; bpm, beat per minute.