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. 2022 Mar 22;10:754344. doi: 10.3389/fbioe.2022.754344

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Copyright © 2022 Zhou, Li, Domel, Dennis, Georgiadis, Liu, Raymond, Grant, Kleiven, Camarillo and Zeineh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the 95th percentile maximum principle strain and strain rate in the hippocampal subfields and the whole hippocampus between the TH-Model and NTH-model of three concussive impacts (Cases 1–3) and three sub-concussive impacts (Cases 4–6). (A) Comparison of strain in the hippocampal subfields of three concussive impacts. (B) Comparison of strain in the hippocampal subfields of three sub-concussive impacts. (C) Comparison of strain rate in the hippocampal subfields of three concussive impacts. (D) Comparison of strain rate in the hippocampal subfields of three sub-concussive impacts. Percentages in strain difference and strain rate difference are calculated with the results of the NTH-Model as the baseline. CA: cornu ammonis; DG: dentate gyrus; HP Tail: hippocampal tail.