Table 2. Univariate and multivariate Cox proportional hazards analysis of preoperative factors for duration of postoperative chemotherapy.
| Variables | Cutoff | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age | <74 | 1.00 | |||||
| ≥74 | 6.79 | 3.16–15.44 | <0.01 | 5.24 | 2.19–12.96 | <0.01 | |
| Sex | Male | 1.00 | |||||
| Female | 1.28 | 0.57–2.72 | 0.54 | ||||
| BMI | <20.8 | 1.29 | 0.59–2.72 | 0.51 | |||
| ≥20.8 | 1.00 | ||||||
| Preoperative symptoms | Yes | 1.02 | 0.47–2.48 | 0.95 | |||
| No | 1.00 | ||||||
| Diabetes mellitus | Yes | 1.00 | |||||
| No | 1.32 | 0.51–4.50 | 0.59 | ||||
| Cardiovascular comorbidities | Yes | 1.91 | 0.90–4.07 | 0.09 | |||
| No | 1.00 | ||||||
| Respiratory comorbidities | Yes | 1.87 | 0.78–4.10 | 0.15 | |||
| No | 1.00 | ||||||
| Cerebrovascular disease | Yes | 2.02 | 0.48–5.77 | 0.29 | |||
| No | 1.00 | ||||||
| PS | 0 | 1.00 | |||||
| 1 | 2.10 | 0.99–4.62 | 0.05 | ||||
| ASA physical status | 1 | 1.00 | |||||
| 2,3 | 1.53 | 0.66–4.15 | 0.34 | ||||
| Neoadjuvant chemotherapy | Yes | 1.00 | |||||
| No | 4.12 | 0.88–73.38 | 0.08 | ||||
| CEA | <4.7 | 3.02 | 0.90–18.76 | 0.08 | |||
| ≥4.7 | 1.00 | ||||||
| CA19-9 | <9.8 | 2.56 | 1.19–5.96 | 0.02 | 1.96 | 0.89–4.66 | 0.10 |
| ≥9.8 | 1.00 | ||||||
| Total protein | <6.2 | 1.33 | 0.45–3.24 | 0.57 | |||
| ≥6.2 | 1.00 | ||||||
| Albumin | <4.2 | 1.83 | 0.85–4.25 | 0.12 | |||
| ≥4.2 | 1.00 | ||||||
| Total bilirubin | <0.54 | 1.35 | 0.63–2.85 | 0.43 | |||
| ≥0.54 | 1.00 | ||||||
| ALBI | <−0.37 | 2.93 | 0.87–18.16 | 0.09 | |||
| ≥−0.37 | 1.00 | ||||||
| CONUT score | 0–2 | 1.00 | |||||
| 3–7 | 2.65 | 1.22–5.59 | 0.01 | 1.50 | 0.55–4.16 | 0.43 | |
| NRS-2002 | 2, 3 | 1.00 | |||||
| 4, 5, 6 | 2.31 | 1.10–4.95 | 0.03 | 1.15 | 0.49–2.73 | 0.74 | |
| Onodera’s PNI | <48.3 | 2.38 | 1.13–5.25 | 0.02 | 1.47 | 0.57–3.74 | 0.42 |
| ≥48.3 | 1.00 | ||||||
| LMR | <3.7 | 1.31 | 0.61–2.75 | 0.48 | |||
| ≥3.7 | 1.00 | ||||||
| NLR | <1.9 | 1.00 | |||||
| ≥1.9 | 2.02 | 0.87–5.49 | 0.10 | ||||
| PLR | <157 | 1.00 | |||||
| ≥157 | 2.02 | 0.94–4.69 | 0.07 | ||||
| PNR | <1.00 | 1.00 | |||||
| ≥1.00 | 3.97 | 1.19–24.63 | 0.02 | 2.76 | 0.77–17.60 | 0.13 | |
| SIS | 0, 1 | 1.00 | |||||
| 2 | 1.98 | 0.88–4.23 | 0.10 | ||||
HR = hazard ratio; CI = confidence interval; ASA = American Society of Anesthesiologists; BMI = body mass index; PS = performance status; CEA = carcinoembryonic antigen; CA19-9 = carbohydrate antigen 19-9; ALBI = albumin-to-bilirubin index; CONUT = controlling nutritional status; NRS = nutritional risk screening; PNI = prognostic nutritional index; LMR = lymphocyte-to-monocyte ratio; NLR = neutrophil-to-lymphocyte ratio; PLR = platelet-to-lymphocyte ratio; PNR = platelet-to-neutrophil ratio; SIS = systemic inflammation score.