TABLE 3.

Per-patient and per-vessel diagnostic performance of coronary CTA and CT-FFR.

	Per-patient			Per-vessel
	CTA stenosis ≥ 50%	CT-FFR ≤ 0.8	P Value	CTA stenosis ≥ 50%	CT-FFR ≤ 0.8	P Value
Sensitivity (%)	88.9 (143/161) [85.1, 94.2]	90.7 (146/161) [86.4, 95.2]	0.474	89.3 (151/169) [84.3, 93.2]	89.9 (152/169) [84.1, 94.3]	1.000
Specificity (%)	37.2 (58/156) [25.5, 39.2]	90.4 (141/155) [90.1, 98.3]	<0.0001	35.5 (70/197) [29.4, 43.3]	87.8 (173/197) [80.1, 90.5]	<0.0001
Accuracy (%)	63.4 (201/317) [56.2, 67.3]	90.5 (288/317) [87.7, 94.2]	<0.0001	60.4 (221/366) [55.5, 65.1]	88.8 (325/366) [85.4, 92.6]	<0.0001
PPV (%)	59.3 (143/241) [52.3, 64.5]	90.7 (146/161) [84.2, 94.7]	<0.0001	54.3 (151/278) [48.3, 60.1]	87.3 (152/174) [81.1, 91.6]	<0.0001
NPV (%)	76.3 (58/76) [65.2, 85.4]	90.4 (141/156) [85.3, 95.5]	0.04	79.5 (70/88) [70.2, 87.6]	91.1 (173/190) [89.4, 96.2]	0.006
AUC	0.64 [0.58, 0.69]	0.92 [0.88, 0.95]	<0.0001	0.66 [0.60, 0.70]	0.89 [0.86, 0.92]	<0.0001

Numerators and denominators are in parentheses; 95% confidence intervals are in brackets.

NPV, negative predictive value; PPV, positive predictive value; AUC, area under the curve; CTA, computed tomographic angiography; CT-FFR, fractional flow reserve derived from computed tomography.