TABLE 5.
Computed tomography angiography characteristics on FP and FN lesions by CT-FFR in different FFR level.
| FFR < 0.76 (n = 119) |
0.76 ≤ FFR ≤ 0.8 (n = 50) |
FFR > 0.8 (n = 197) |
|||||||
| CT-FFR > 0.8(FN) (n = 7) |
CT-FFR ≤ 0.8(TP) (n = 112) |
P Value | CT-FFR > 0.8(FN) (n = 10) |
CT-FFR ≤ 0.8(TP) (n = 40) |
P Value | CT-FFR > 0.8(TN) (n = 176) |
CT-FFR ≤ 0.8(FP) (n = 21) |
P Value | |
| LAD | 6 | 87 | 1.000 | 8 | 35 | 0.616 | 96 | 12 | 0.577 |
| ICA > 50% | 6 | 95 | 1.000 | 7 | 23 | 0.689 | 81 | 13 | 0.182 |
| Agatston score of target lesion | 40.8 (4.8, 126.1) |
45.6 (6.1, 194.3) |
0.566 | 4.16 (1.16, 47.68) | 28.2 (30.26, 67.53) | 0.037 | 29 (0, 120) |
118.3 (31.3, 257.5) |
0.029 |
| Plaque burden of target lesion (%) | 53.2 (41.0, 60.0) |
54.6 (47.1, 61.8) |
0.658 | 55.6 (46.7, 59.9) |
50.8 (44.2, 58.0) |
0.308 | 46.1 (36.9, 56.0) |
56.0 (46.8, 62.6) |
0.033 |
| Calcified volume of target lesion (mm3) | 7.2 (0.8, 42.7) |
9.0 (0.2, 53.1) |
0.630 | 4.5 (0, 51) |
38.2 (8.2, 94.2) |
0.034 | 4.2 (0, 28.3) |
27.1 (8.5, 83.1) |
0.012 |
| Lumen area of target lesion (mm2) | 2.5 (1.7, 3.6) |
1.7 (1.2, 2.4) |
0.048 | 2.6 (2.4, 3.1) |
2.2 (1.6, 2.9) |
0.119 | 2.5 (1.9, 3.2) |
2.3 (1.7, 2.6) |
0.128 |
| Lumen diameter of target lesion (mm) | 1.8 (1.5, 2.2) |
1.5 (1.2, 1.7) |
0.047 | 1.8 (1.7, 2.0) |
1.7 (1.4, 1.9) |
0.119 | 1.8 (1.5, 2.0) |
1.7 (1.5, 1.8) |
0.803 |
Data are median, interquartile range are in parentheses.
Comparison of plaque burden between TP and FN in FFR < 0.76 and 0.76–0.8 groups, TN and FP in FFR > 0.8 group are shown.
LAD, left anterior descending artery; ICA, invasive coronary angiography; FFR, fractional flow reserve; CT-FFR, fractional flow reserve derived from computed tomography; FN, false negative; FP, false positive; TN, true negative; TP, true positive.