TABLE 4.
Yeast strain sensitivity to NCI compounds
| Compound | Yeast inhibition (cm in spoke assay)a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Cp-yeast type I | Cp-yeast type II | Hu-yeast | Pf-yeastS | Pf-yeastR | Tg-yeast | Pc-yeast | Sc-yeast | |
| Trimetrexate | 2.3 | 2.5 | 2.9 | >3.5 | 3 | 2.7 | 1.8 | −b |
| 61670 | − | − | − | >2 | − | − | − | − |
| 104126 | − | − | − | 0.9 | − | − | − | − |
| 106568 | 1.5 | 2 | − | >2.5 | 1.6 | − | − | − |
| 107242 | − | − | − | >1.7 | − | − | − | − |
| 112421 | 1.2 | 1.6 | 1.4 | >2.2 | − | − | − | − |
| 117288 | 0.6 | 0.6 | 0.7 | 1.8 | 0.9 | 0.9 | 0.6 | 0.7 |
| 121146 | 1.1 | 1.2 | 1.5 | >2.2 | − | − | − | − |
| 3081 | − | − | 1.8 | >2.3 | 2.8 | 2 | − | − |
| 47532 | − | − | − | − | − | − | − | − |
| 77028 | − | − | − | − | − | − | − | − |
| 104133 | − | − | 0.9 | >2.5 | 2.4 | 1.2 | − | − |
| 114923 | − | − | − | 0.9 | − | − | − | − |
| 127916 | − | − | − | >2.1 | − | − | − | − |
| Chlorasquin | 1.9 | 2.2 | 2.1 | >3 | 2.3 | 1.7 | 2 | − |
a
Numbers represent distance from the center of the plate to the beginning of yeast growth (kill zone) and are the averages of three independent experiments. The standard deviations were ≤0.5 cm. Pf-yeastS, pyrimethamine-sensitive Pf-yeast; Pf-yeastR, pyrimethamine-resistant Pf-yeast.
b
−, no inhibition detected.