Fig. 2. Acute and repeated administration of pimavanserin plus lorcaserin suppress cocaine-seeking behavior during abstinence.
(A) Effects of acute and repeated pimavanserin (3 mg/kg) on cue-reinforced or inactive lever presses (mean ± SEM) on FA 10 are presented (*p < 0.05 vs. control). (B) Effects of acute and repeated lorcaserin (1 mg/kg) on cue-reinforced or inactive lever presses (mean ± SEM) are presented (*p < 0.05 vs. control cue-reinforced; ^p < 0.05 vs. control inactive). (C) Effects of acute and repeated combination of pimavanserin (0.5 mg/kg) plus lorcaserin (0.5 mg/kg) on cue-reinforced or inactive lever presses (mean ± SEM) on FA 10 are presented (*p < 0.05 vs. control cue-reinforced).