Table 2.

Pharmacokinetic parameters of pimavanserin or lorcaserin following a single dose of each medication alone or in combination (mean ± SEM).

	CMAX (ng/ml)	TMAX (hr)	AUC0-t(ng-hr/ml)	AUC0-inf(ng-hr/ml)	AUCExtrap(%)	λ(1/hr)	Half-life, t1/2(hr)	Cl/F(L/hr/kg)
Pimavanserin
Pimavanserin(mg/kg; s.c.)
0.5	12.17 ± 0.38	0.29 ± 0.04	14.40 ± 0.31	15.02 ± 0.32	3.89 ± 1.42	0.76 ± 0.14	1.29 ± 0.45	33.40 ± 0.73
1	30.13 ± 2.17	0.25 ± 0.00	41.27 ± 2.64	41.72 ± 2.7	1.09 ± 0.28	0.79 ± 0.04	0.89 ± 0.05	24.55 ± 1.81
3	79.52 ± 3.76	0.38 ± 0.06	189.33 ± 7.75	197.5 ± 8.33	4.26 ± 0.68	0.59 ± 0.03	1.18 ± 0.05	15.28 ± 0.65
10	213.17 ± 15.86	0.96 ± 0.25	857.50 ± 54.72	1290.17 ± 112.09	32.22 ± 4.18	0.21 ± 0.02	3.63 ± 0.54	8.10 ± 0.83
Pim + Lora(mg/kg; s.c.)
0.5 + 0.5	12.03 ± 1.97	0.25 ± 0.00	13.88 ± 3.32	14.34 ± 3.47	2.90 ± 0.69	0.80 ± 0.09	0.93 ± 0.12	41.15 ± 5.30
1 + 1	26.87 ± 5.04	0.25 ± 0.00	38.18 ± 11.19	39.05 ± 11.56	1.90 ± 0.44	0.68 ± 0.05	1.05 ± 0.08	28.00 ± 7.26
Lorcaserin
Lorcaserin(mg/kg; s.c.)
0.5	15.63 ± 0.74	0.29 ± 0.04	29.03 ± 0.53	33.43 ± 1.31	12.68 ± 2.45	0.31 ± 0.03	2.39 ± 0.33	15.07 ± 0.56
1	34.35 ± 3.19	0.25 ± 0.00	58.52 ± 3.41	63.70 ± 3.91	8.06 ± 0.47	0.39 ± 0.02	1.80 ± 0.09	15.97 ± 0.85
3	106.33 ± 14.74	0.42 ± 0.05	183.50 ± 7.71	199.17 ± 8.24	7.97 ± 0.50	0.38 ± 0.01	1.83 ± 0.07	15.18 ± 0.66
Pim + Lora(mg/kg; s.c.)
0.5 + 0.5	14.74 ± 0.71	0.30 ± 0.05	26.46 ± 1.80	28.48 ± 1.88	7.14 ± 0.75	0.40 ± 0.02	1.74 ± 0.11	17.9 ± 1.29
1 + 1	26.62 ± 1.69	0.35 ± 0.06	48.88 ± 2.71	52.82 ± 2.84	7.55 ± 0.52	0.41 ± 0.02	1.71 ± 0.07	19.12 ± 0.99

^aPimavanserin administered 15 min prior to lorcaserin; C_MAX, maximum serum concentration; T_MAX, time to reach C_MAX; AUC_0-t, area under plasma drug concentration-time curve (AUC) up to time ‘t’; AUC_0-inf, extrapolated AUC to infinity; AUC_Extrap, effect of extrapolated AUC on AUC_0-inf estimation; λ, individual estimate of terminal elimination rate constant; t_1/2, elimination half-life; Cl/F, apparent total body clearance.